GREENVILLE, S.C. --Jordan Lewis added 13 points and freshman Ashley Knight set the school record for blocked shots, rejecting three to give her 71 for the Crimson Tide (18-12).
Rachel Bell had a career-high 31 points for the Commodores (14-15), who had won five straight over Alabama.
Both teams shot 50 percent in the first half but the Tide had a 42-30 lead by going 6-of-10 from 3-point range and 10-of-14 at the foul line compared to 1-of-4 and 1-of-5, respectively, for Vandy.
Alabama took control by scoring the first six points of the third quarter and putting together a late 8-0 run, making it 60-40 on a jumper by Meoshonti Knight, who had 10 points. The 77 points is the most Alabama has scored in the tourney since scoring 76 in the second round in 1999.
Vanderbilt, one of the top 3-point teams in the country at 39 percent with 7.3 makes a game, finished 3-of-16 (18.8).
UP NEXT: Alabama faces No. 5 seed Tennessee tomorrow on SEC Network in the Second Round in Game 4, approximately 30 minutes after the conclusion of Game 3 between No. 8 seed Georgia and No. 9 seed Auburn. Game 3 is set to tip off at Noon ET.