AMES, Iowa -- Bryce Dejean-Jones had 27 points, Georges Niang added 26 with eight assists and 20th-ranked Iowa State never trailed in rolling past No. 18 Arkansas 95-77 on Thursday night.
Dustin Hogue scored 14 for the Cyclones (5-1), who led by as many as 23 points in extending their non-conference home winning streak to 24 games.
Iowa State's fast-break offense overwhelmed the Razorbacks (6-1) from the opening tip. The Cyclones took their first double-digit lead less than six minutes in and led 52-32 at the break.
Bobby Portis scored 19 to lead the Razorbacks (6-1), who haven't won a road game as a ranked team since 1999.
This was billed as potentially one of the highest-scoring games of the season. Arkansas entered ranked fourth nationally at 90 points per game, and Iowa State was averaging 83.4 points through five games.
The Razorbacks knew they were in trouble once they found themselves down 15 after 12 minutes -- even though they were shooting 50 percent from the field.
Iowa State pushed the tempo better than it had all season, and the Arkansas defense appeared powerless to stop the Cyclones.
Iowa State went on a 13-0 run midway through the first half to go up 39-20, and Niang's layup made it 48-26 with 2:26 left.
The Cyclones hit 18 of their first 28 shots -- with assists on 13 of their made baskets -- and nailed seven 3-pointers in the first 20 minutes.
Portis hit a few shots early to keep Arkansas briefly within striking distance, and its press defense caused Iowa State some issues in the second half.
But it was clear from the early stages that the Razorbacks were headed to their first loss of the season.
Alandise Harris had 15 points for Arkansas, which never got within single digits in the second half.
Arkansas: Though Arkansas had only visited Ames once prior to Thursday, coach Mike Anderson knows the Cyclones well. He went 8-2 against Iowa State as the head coach at Missouri. ... The Razorbacks had assists on 14 of their first 16 shots -- yet trailed 61-38.
Iowa State: Niang was named to the Naismith Trophy watch list on Wednesday. Niang averaged 18.2 points, 6.6 rebounds and three assists in Iowa State's first five games. He was even better against Arkansas, going 9 of 12 from the floor and 6 of 6 from the line.
Arkansas plays at Clemson on Sunday.
Iowa State hosts Missouri-Kansas City on Dec. 9.