COLUMBIA, Mo. -- Kentrell Brothers had a career-best 16 tackles and blocked a punt that was returned for a touchdown for No. 24 Missouri, which opened with a 34-3 victory over Southeast Missouri State on Saturday.

Aarion Penton caught the blocked punt, a quick kick by quarterback Tay Bender that backfired, in the air for a 41-yard return late in the third quarter that made it 27-3.

Maty Mauk threw two touchdown passes in the first quarter and freshman backup Drew Lock threw a 78-yard touchdown pass to Tyler Hunt in the fourth for Missouri.

Mauk was 12 of 22 for 181 yards with an interception and Lock was 6 of 8 for 138 yards.

Bender was more effective running than passing. He gained 69 yards on 14 carries and was 12 of 22 for 56 yards.

Missouri lost running back Russell Hansbrough and center Evan Boehm in the first half with sprained ankles. Hansbrough had his right leg in a cast after the break.

Southeast Missouri State had one good drive, going 76 yards on 16 plays to set up a 35-yard field goal by Ryan McCrum in the second quarter.