BATON ROUGE, La. -- Ed Orgeron held both arms in the air as he emerged from the Tiger Stadium tunnel for his first game as LSU's interim coach. Derrius Guice's long, crowd-thrilling touchdown runs ensured Orgeron would have every reason to leave Death Valley in an even better mood.

In the first game since the firing of coach Les Miles, and with star running back Leonard Fournette sidelined with ankle soreness, Guice rushed for a career-high 163 yards and three touchdowns, leading LSU to a 42-7 victory over Missouri on Saturday night.

Orgeron walked of the field beaming after his players gave him a celebratory drenching with a bucket of sports drink and handed him a game ball.

Guice scored the game's first touchdown on a zig-zagging, 42-yard run in which he left several would-be tacklers grasping at air before using his speed to race away for the final yards. He added TDs from 4 and 37 yards before the first half ended.

Darrel Williams added a career-high 130 yards and three short touchdowns for LSU (3-2, 2-1 Southeastern Conference), which finished with 418 yards on the ground.

Missouri (2-3, 0-2) struggled to sustain drives and didn't score until executing a reverse pass from receiver Eric Laurent to quarterback Drew Lock with 6:11 left in the game. LSU dominated time of possession, 42:42 to 17:18 and ran 82 plays to Missouri's 60. LSU also finished with 634 yards -- the school record for an SEC game- to Missouri's 265.

Getting rid of the ball quickly, Lock limited LSU's formidable pass rush to two sacks. But LSU's secondary didn't give the quarterback many easy throws. Lock, who came in averaging 377 yards passing, finished 17 of 37 for 167 yards and was intercepted once by Tre'Davious White on a long, over-thrown pass.

Miles, arguably the most successful coach in LSU history after winning 77 percent of his games in 11-plus seasons -- including the 2007 national championship -- was fired last Sunday, the day after an 18-13 loss at Auburn. That game marked the second time this season LSU's offense looked stagnant in a loss to an underdog that was not ranked at the time of the game.

Orgeron promised a different look on offense and delivered early with four wide-receiver sets and enough passes to keep Missouri's defense honest. But statistically, LSU looked a lot like some of Miles' most dominant teams, with more yards and scoring on the ground than through the air.

LSU QB Danny Etling completed 19 of 30 for 216 yards and did not turn the ball over.

THE TAKEAWAY

After falling out of the AP Poll last week, LSU could very well jump right back into the ranking with its emphatic rebound from its last-second lost at Auburn.

UP NEXT

MISSOURI: After a bye next weekend, Missouri will visit Florida on Oct. 15.

LSU: A clash with historical rival Florida in the Swamp next weekend is on tap for LSU, marking the first road game of the Orgeron era.